Based on international literature, preliminary experiences in a three-country West African research programme, and on the disappointing impact of agricultural research on African farm innovation, the current paper argues that institutional change demands rethinking the pathways to innovation so as to acknowledge the role of rules, distribution of power and wealth, interaction and positions. The time is opportune: climate change, food insecurity, high food prices and concomitant riots are turning national food production into a political issue also for African leaders.