A worthy agricultural innovation system (AIS) is one that that helps an agricultural sector be productive, sustainable and resilient and facilitates reduction in poverty and malnutrition. How can an AIS be made resilient in the context of the COVID-19 pandemic is a question pondered in this note. The key issue will be continued strong investment in knowledge and technology creation that underpins growth in productivity and the active pursuit of mechanisms that make agriculture more resilient to the emerging environments challenges around the world.