This work examined the determinants of the adoption of improved Irish potato technologies by farmers in three divisions of the Western Region of Cameroon. Data were collected from 170 farmers from 14 villages in our study area using a mixed-method approach—structured questionnaires, focus group discussion, key informant interviews, and participatory observations with individual farmers and farmers belonging to cooperative and common initiative groups. The study employed descriptive statistics and regression analysis to assess the adoption status of farmers and its determinants.