These Proceedings report on the second International Conference of the Convergence of Sciences (CoS) programme in Elmina (2009). The first International Conference was four years earlier in the same location, where it was discussed how to follow up on the findings of the first CoS Programme phase (entitled CoS1 running from 2001 to 2006). The Conference was intended to introduce the focus on “innovation systems”, and how to enhance these systems for smallholder farmers’ development.