This paper represents a guidance to USAID on elements to incorporate into a strategy to improve agricultural research, and a technical brief to guide USAID investments in NARS strengthening. The paper is the final output from a one-day Roundtable which was held on March 5, 2013 and that brought together some 30 specialists in agricultural research and agricultural research systems to discuss which USAID interventions would best strengthen NARS in developing countries.