This article presents programmatic lessons on scaling up research for development innovations that were implemented through the Canadian International Food Security Research Fund (CIFSRF). Co-funded by the International Development Research Center (IDRC) and Global Affairs Canada (GAC), CIFSRF was a nine-year, two-phased program (2009–2018) that supported applied research to develop, test and scale proven food and nutrition security innovations. The outline of this paper is as follows.