This article presents a multi-stakeholder framework for intervening in root, tuber, and banana seed systems and in other VPCs. These crops are reproduced not with true seed but with vegetative planting material (e.g., roots,tubers, vines, stems, and suckers), called “seed” in this article. Seed systems for VPCs need to be designed differently than those for true seed, and coordination among stakeholders in seed systems is crucial