Research-based evidence on the adoption of climate-smart agricultural practices is vital to their effective uptake, continued use and wider diffusion. In addition, an enabling policy environment at the national and regional levels is necessary for this evidence to be used effectively. This chapter analyzes a 4-year period of continuous policy engagement in East Africa in an attempt to understand the role of multi-stakeholder platforms (MSPs) in facilitating an enabling policy environment for climate change adaptation and mitigation.